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JNCI Journal of the National Cancer Institute 2001 93(15):1122-1123; doi:10.1093/jnci/93.15.1122
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 15, 1122-1123, August 1, 2001
© 2001 Oxford University Press

EDITORIAL

Ovarian Tumors of Low Malignant Potential: Can Molecular Biology Solve This Enigma?

Ginger J. Gardner , Michael J. Birrer

Affiliation of authors: Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.

Correspondence to: Michael J. Birrer, M.D., Ph.D., Key West Research Center, 9610 Medical Center Dr., Bldg. C, Rm. 300, Rockville, MD 20850 (e-mail: birrerm@BPRB.NCI.NIH.GOV).

Borderline tumors of the ovary, originally described by Taylor (1) in 1929, were officially recognized by the International Federation of Gynecology and Obstetrics and the World Health Organization approximately 30 years ago. Despite their long-standing recognition as a distinct entity, they remain an oncologic enigma. Borderline tumors, also referred to as ovarian tumors of low malignant potential, are defined pathologically by epithelial proliferations, multicellular layering, mitotic activity, and atypical nuclear structures similar to invasive ovarian cancer, but without evidence of stromal invasion (2). Ovarian tumors of low malignant potential are most frequently diagnosed as early-stage tumors; however, they can present with widespread metastatic intra-abdominal disease (3). On the basis . . . [Full Text of this Article]

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