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JNCI Journal of the National Cancer Institute 2001 93(15):1119-1120; doi:10.1093/jnci/93.15.1119
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 15, 1119-1120, August 1, 2001
© 2001 Oxford University Press

EDITORIAL

Understanding Mechanisms of Breast Cancer Prevention

Robert N. Hoover, Rebecca J. Troisi

Affiliation of authors: Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

Correspondence to: Robert N. Hoover, M.D., Sc.D., National Institutes of Health, 6120 Executive Blvd., Bethesda, MD 20892–7246 (e-mail: hooverr@mail.nih.gov).

Several relatively strong risk factors for breast cancer that affect large proportions of the general population have been known for some time. Nevertheless, few effective preventive interventions have been developed, probably because most of the recognized risk factors relate to reproductive factors that are, in a practical sense, nonmodifiable. The response to this situation has been enthusiasm for identifying the underlying biologic mechanisms associated with these recognized risk factors, with the expectation that these mechanisms could be exploited directly rather than altering the risk factors responsible for them. An example is the solid evidence from both laboratory and population studies of the . . . [Full Text of this Article]

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