© 2001 by Oxford University Press
Journal of the National Cancer Institute, Vol. 93, No. 14, 1106-1108,
July 18, 2001
© 2001 Oxford University Press
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Cyclin D1 Polymorphism and Increased Risk of Colorectal Cancer at Young Age
Affiliation of authors: Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston.
Correspondence to: Marsha L. Frazier, Ph.D., Box 189, Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030.
Colorectal cancer is the third most common cause of cancer and cancer mortality among men and women in the United States. It is estimated that there will be approximately 130 400 new colorectal cancer cases and 56 700 deaths in the year 2001 (1).
Cyclin D1 is involved both in normal regulation of the cell cycle and in neoplasia, where it is frequently overexpressed (2). It plays an important role in the transition from the G1 phase to the S phase of the cell cycle. Amplification or overexpression of the cyclin D1 gene (also known as CCND1) is common in a variety of different cancers and induces proliferation.
The cyclin D1 gene has a G to A polymorphism at codon 242 in exon 4 that increases the frequency of alternate splicing (3). In the alternately spliced RNA, intron 4 is not spliced out. Both
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