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JNCI Journal of the National Cancer Institute 2001 93(14):1044-1046;
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 14, 1044-1046, July 18, 2001
© 2001 Oxford University Press

NEWS

Cancer Vaccines: Advances Give Hope For Future Therapy

Tracy Thompson

Newspapers around the country have touted cancer vaccines as offering new hope for cancer treatment. A National Cancer Institute Web site lists nine phase III clinical trials and 64 phase II trials testing cancer vaccines. Excitement is building in the cancer vaccine field.

"The notion that somehow we can use the immune system to recognize and destroy cancer is not a new idea, but it has been very difficult to make it work," said Edgar Engleman, M.D., professor of pathology and of medicine at Stanford University.

Similar to vaccines against viruses like poliovirus, a cancer vaccine seeks to show the body what it should be battling. Bacteria and viruses produce antigens that are very different from those on the patient’s normal cells. Because of this, the antigens are easily recognized by the immune system.

In contrast, tumor antigens are likely to be similar or even identical to antigens on normal . . . [Full Text of this Article]

When to Treat?

Which Tumor Antigen?

Mode of Delivery

Dendritic Cells

Future Directions


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