© 2001 by Oxford University Press
Journal of the National Cancer Institute, Vol. 93, No. 14, 1040-1041,
July 18, 2001
© 2001 Oxford University Press
EDITORIAL |
Angiogenic Heterogeneity: Regulation of Neoplastic Angiogenesis by the Organ Microenvironment
Correspondence to: Isaiah J. Fidler, D.V.M., Ph.D., Department of Cancer Biology-173, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030 (ifidler@mdanderson.org).
Cells cannot survive if they lack adequate oxygen and nutrient supply or cannot dispose of toxic molecules. Oxygen can diffuse from capillaries for only 150–200 µm. When distances of cells from a blood supply exceed this, cell death follows (1,2). Thus, the growth and survival of tumor masses beyond 0.5 mm in diameter require neovascularization, i.e., angiogenesis (3).
In this issue of the Journal, Achilles et al. (4) injected human liposarcoma cells (tumor fragments or cells) into the subcutis of severe combined immunodeficient mice. The different tumor fragments and liposarcoma cells gave rise to fast-growing, slow-growing, or small dormant tumors. The growth rate of the tumors correlated directly with microvessel density and correlated inversely with tumor cell apoptosis.
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