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JNCI Journal of the National Cancer Institute 2001 93(12):890-891; doi:10.1093/jnci/93.12.890
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 12, 890-891, June 20, 2001
© 2001 Oxford University Press

EDITORIAL

Epidermal Growth Factor Receptor Signaling and Response of Cancer Cells to Ionizing Radiation

Stephen P. Ethier, Theodore S. Lawrence

Affiliation of authors: Department of Radiation Oncology, The University of Michigan, Ann Arbor.

Correspondence to: Theodore S. Lawrence, M.D., Ph.D., Department of Radiation Oncology, The University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI 48109–0010 (e-mail: tsl@umich.edu).

The epidermal growth factor receptor (EGFR) is now recognized as an important target for therapeutic interventions in many types of cancer. Because of the prognostic significance of EGFR expression in cancer and the laboratory data that provide direct evidence for aberrant EGFR signaling in cancer cells, this growth factor receptor is being targeted clinically with the use of both antibody- and small molecule-based approaches (1). In this issue of the Journal, Lammering et al. (2) extend their previous observations on the usefulness of targeting the EGFR to improve the therapeutic efficacy of ionizing radiation. Previously, these investigators demonstrated that exposure of EGFR-positive human breast cancer cells to therapeutically relevant . . . [Full Text of this Article]

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