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JNCI Journal of the National Cancer Institute 2001 93(11):800-801; doi:10.1093/jnci/93.11.800
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 11, 800-801, June 6, 2001
© 2001 Oxford University Press

NEWS

Telomerase Still ‘Investigational’ in Its Application to Cancer Management

Judith Randal

Although the field had barely begun less than a generation ago, telomere-telomerase biology was the main topic of symposia and discussion sessions at the annual meeting of the American Association of Cancer Research held in New Orleans this year.

Telomerase, an enzyme, is essential for the assembly of telomeres, repetitive DNA sequences on the ends of chromosomes that help to preserve their structural integrity. But Jerry W. Shay, Ph.D., a cell biologist in the Department of Internal Medicine at the University of Texas Southwestern Medical Center, Dallas, noted that, with certain exceptions (notably in the germ cells that give rise to eggs and sperm), telomerase makes itself scarce once the telomeres are complete.



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  		Dr. Jerry W. Shay

 
Lacking Access

In brief, telomeres lacking access to telomerase shorten a little each time the cells that host them . . . [Full Text of this Article]

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