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JNCI Journal of the National Cancer Institute 2001 93(11):798-799; doi:10.1093/jnci/93.11.798
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 11, 798-799, June 6, 2001
© 2001 Oxford University Press

EDITORIAL

Stool DNA-Based Colorectal Cancer Detection: Finding the Needle in the Haystack

Wendy Atkin, John P. Martin

Affiliation of authors: Imperial Cancer Research Fund (ICRF) Colorectal Cancer Unit, St. Mark's Hospital, Harrow, Middlesex, U.K.

Correspondence to: Wendy Atkin, M.P.H., Ph.D., ICRF Colorectal Cancer Unit, St. Mark's Hospital, Northwick Park, Watford Rd., Harrow, Middlesex, HA1 3UJ, U.K. (e-mail: atkin@icrf.icnet.uk).

For many centuries, it has been suspected that examination of stool could provide insights into the state of health or disease of an individual. The Egyptians were concerned with the shape and consistency of stool (Eber's papyrus, 207), and 19th century Americans were concerned with "poisons and gases" (1); more recently, the components of stool (e.g., pathogens, occult blood, fats, and bile acids) have been the subject of scrutiny.

Within the past two decades, with the advent of the polymerase chain reaction (PCR) technique, came the ability to amplify tiny numbers of specific DNA sequences. This advance has permitted the identification of not only mutations that accumulate in neoplasms and define their progression to . . . [Full Text of this Article]

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