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JNCI Journal of the National Cancer Institute 2001 93(10):734-735; doi:10.1093/jnci/93.10.734
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 10, 734-735, May 16, 2001
© 2001 Oxford University Press

EDITORIAL

A New Link in Ovarian Cancer Angiogenesis: Lysophosphatidic Acid and Vascular Endothelial Growth Factor Expression

Judah Folkman

Correspondence to: Judah Folkman, M.D., Children's Hospital, Hunnewell 103, 300 Longwood Ave., Boston, MA 02115 (e-mail: Judah.Folkman@tch.harvard.edu).

The switch to the angiogenic phenotype (1) is under genetic and epigenetic regulation. An example of genetic regulation of the angiogenic switch is expression of the HER-2/neu oncogene, which increases expression of vascular endothelial growth factor (VEGF), a positive regulator of angiogenesis in human breast cancer (2). Another example is expression of the ras oncogene, which increases expression of VEGF and decreases expression of thrombospondin-1, a negative regulator of angiogenesis. At least 13 other oncogenes are known to encode proteins that drive tumor angiogenesis (2). By contrast, certain tumor suppressor genes . . . [Full Text of this Article]

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