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JNCI Journal of the National Cancer Institute 2001 93(10):733; doi:10.1093/jnci/93.10.733
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 10, 733, May 16, 2001
© 2001 Oxford University Press


EDITORIAL

Is Hormone Replacement Therapy Safe for Breast Cancer Patients?

Jack Cuzick

Correspondence to: Jack Cuzick, Ph.D., Imperial Cancer Research Fund, 61 Lincoln's Inn Fields, London WC2A 3PX, U.K. (e-mail: cuzick@icrf.icnet.uk).

The fundamental role of estrogens in the development of breast cancer is now well recognized. This role can be seen most clearly in the postmenopausal age range, where several studies have found that serum levels of endogenous estradiol are higher in women who develop breast cancer [reviewed in (1)]. Also, obesity, which is associated with increased postmenopausal estrogen production, is a clearly established risk factor for postmenopausal breast cancer. Likewise, the continuance of premenopausal status is a strong risk factor for breast cancer, and the risk is increased by about 2.8% for each additional year . . . [Full Text of this Article]

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