In Utero Exposures and Breast Cancer: a Study of Opposite-Sexed Twins

doi:10.1093/jnci/93.1.60

JNCI Journal of the National Cancer Institute 2001 93(1):60-62; doi:10.1093/jnci/93.1.60
© 2001 by Oxford University Press

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Journal of the National Cancer Institute, Vol. 93, No. 1, 60-62, January 3, 2001
© 2001 Oxford University Press

BRIEF COMMUNICATION

In Utero Exposures and Breast Cancer: a Study of Opposite-Sexed Twins

Magnus Kaijser, Paul Lichtenstein, Fredrik Granath, Gunnar Erlandsson, Sven Cnattingius, Anders Ekbom

Affiliation of authors: Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden.

Correspondence to: Magnus Kaijser, M.D., Berzelius väg 15C, S-171 77 Stockholm, Sweden (e-mail: magnus.kaijser@mep.ki.se).

It has been suggested that hormonal exposures in utero influencethe risk of breast cancer later in life (1). Estrogens are well-establishedrisk factors for breast cancer (2), and there is a pronouncedassociation between birthweight and antenatal estrogen exposure(3). Several epidemiologic studies (4–6) have found thatpreeclampsia, a perinatal event characterized by low maternalestrogen levels, is associated with a decreased risk of breastcancer, but the results in different studies (6–8) ofthe association between birthweight and breast cancer risk arenot entirely consistent.

One possible reason for the divergent results could be the narrowrange of antenatal estrogen exposure seen in singleton pregnancies.Twin . . . [Full Text of this Article]

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