© 2000 by Oxford University Press
Journal of the National Cancer Institute, Vol. 92, No. 9, 681-683,
May 3, 2000
© 2000 Oxford University Press
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Multinational Effort Aims to Record All Clinical Trials
Oncologists put their faith in the findings of randomized clinical trials, especially in the sum of evidence from many trials, in determining how best to treat their patients.
But they have to wonder, along with other clinicians, how complete, and how reliable, is the record of published results. For a variety of reasons, the results of many trials never get published, while those of others may be published several times, perhaps in different languages with different authors.
Most troubling is that trials with positive resultsevidence for superior efficacy of a new treatmentare more likely than others to
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