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JNCI Journal of the National Cancer Institute 2000 92(9):675-677; doi:10.1093/jnci/92.9.675
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 9, 675-677, May 3, 2000
© 2000 Oxford University Press

EDITORIALS

Association of Human Papillomaviruses With a Subgroup of Head and Neck Squamous Cell Carcinomas

David T. W. Wong, Karl Münger

Affiliations of authors: D. T. W. Wong, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, MA; K. Münger, Department of Pathology and Harvard Center for Cancer Biology, Harvard Medical School, Boston.

Correspondence to: Karl Münger, Ph.D., Department of Pathology and Harvard Center for Cancer Biology, 200 Longwood Ave., D2/544A, Boston, MA 02115-5701 (e-mail: karl_munger@hms.harvard.edu).

Papillomaviruses, small DNA viruses with a pronounced tropism for epithelial cells, have been isolated from many organisms. In humans, approximately 100 different virus types have been described, and this list is likely to grow. The human papillomaviruses (HPVs) are associated with a large spectrum of epithelial lesions. Most of these are benign hyperplasias (warts) that only very rarely progress to cancers. A subgroup of HPVs, i.e., the "high-risk" HPVs, however, are associated with lesions that have a propensity to undergo carcinogenic progression. Most notably, almost all human cervical carcinomas contain and express high-risk HPV sequences. During carcinogenic progression, the virus frequently becomes integrated into the host genome. Hence, . . . [Full Text of this Article]

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