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JNCI Journal of the National Cancer Institute 2000 92(5):370-372; doi:10.1093/jnci/92.5.370
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 5, 370-372, March 1, 2000
© 2000 Oxford University Press

NEWS

Clinical Trials: Finding Balance In Randomization

Tom Reynolds

Years ago a prominent cancer researcher asked the provocative question, "Is there any mileage left in the randomized clinical trial?"

Emil J. Freireich, M.D., a leukemia expert at the University of Texas M. D. Anderson Cancer Center in Houston, rejected the conventional view of the randomized trial as the gold standard in clinical research. He compared it instead to an old Tin Lizzy, a car that served long and well but is now fit only for museum or junkyard. Answering his own question in the negative, he laid out ethical objections to randomized trials and asserted that many clinical scientists have abandoned such trials as the best way to gather medical knowledge.



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  		Dr. Emil J. Freireich

 
Years later, though, that claim appears overstated—or at least premature. The randomized, controlled trial reigns today as firmly as ever, and researchers have been slow to embrace alternatives or even to modify the . . . [Full Text of this Article]

Equipoise

Justifiably Participate

Eliminating Diversity

Logical Inconsistency

Practicing Informed Consent

Ethical Tensions


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