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JNCI Journal of the National Cancer Institute 2000 92(4):288-289; doi:10.1093/jnci/92.4.288
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 4, 288-289, February 16, 2000
© 2000 Oxford University Press

EDITORIALS

Relation of a Recurrent Intraductal Carcinoma (Ductal Carcinoma In Situ) to the Primary Tumor

Edwin R. Fisher, Bernard Fisher

Affiliations of authors: E. R. Fisher, National Surgical Adjuvant Breast and Bowel Project (NSABP) Pathology Center, Pittsburgh, PA; B. Fisher, NSABP Scientific Director's Office, Pittsburgh.

Correspondence to: Bernard Fisher, M.D., NSABP Scientific Director's Office, Four Allegheny Center, Suite 602, Pittsburgh, PA 15212-5234 (e-mail: bernard.fisher@nsabp.org).

Chromosomal instability has long been recognized as a feature of malignant neoplasms. In 1975 (1,2), we described quantitative differences in chromosomal aberrations in premalignant lesions and in methylcholanthrene-induced cancers in rats; in 1978 (3), we noted these differences between women with both premalignant lesions and breast cancer. The use of digital image analysis of the DNA content of intraductal carcinomas (ductal carcinoma in situ, or DCIS) and the invasive cancers associated with them subsequently (4) revealed a close concordance in DNA ploidy and S-phase content. Although it was tempting to consider our observations as evidence that DCIS was a precursor of the invasive component, we were uncertain whether similarity in itself was a reliable indicator of such a pathogenic pathway, since it was possible that an etiologic agent could have induced the same phenotype in both the large ducts and the ductolobular . . . [Full Text of this Article]

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