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JNCI Journal of the National Cancer Institute 2000 92(3):175; doi:10.1093/jnci/92.3.175
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 3, 175, February 2, 2000
© 2000 Oxford University Press


IN THIS ISSUE

High-Dose Chemotherapy and Breast Cancer

Hortobagyi et al. (p. 225) have conducted a prospective randomized trial involving women with high-risk (of relapse) breast cancer to compare the outcomes of patients treated with standard-dose chemotherapy and patients treated with the same therapy followed by high-dose chemotherapy. Seventy-eight women received eight cycles of 5-fluorouracil, doxorubicin, and cyclophosphamide. They were then randomly assigned to receive no further treatment or to receive two cycles of high-dose cyclophosphamide, etoposide, and cisplatin with autologous hematopoietic stem cell support (bone marrow transplantation). The authors report no relapse-free . . . [Full Text of this Article]

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