© 2000 by Oxford University Press
Journal of the National Cancer Institute, Vol. 92, No. 24, 1966-1967,
December 20, 2000
© 2000 Oxford University Press
EDITORIAL |
-Tocopherol: a New Player in Prostate Cancer Prevention?
Correspondence to: Edward Giovannucci, M.D., Sc.D., Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
In this issue of the Journal, Helzlsouer et al. (1) report findings from a nested case–control study that examines plasma levels of 
-tocopherol, 
-tocopherol, and selenium in relation to incident prostate cancer. The study suggests protective associations for -tocopherol and selenium, although these were not statistically significant, as well as a strong protective association with -tocopherol. In a previous randomized intervention study designed to examine selenium supplementation in relation to recurrent skin cancer (2), a striking 65% reduction in prostate cancer risk was observed among men randomly assigned to receive selenium. In a subsequent nested case–control study (3) of 181 cases of advanced prostate cancer and 181 age-matched control pairs based on toenail selenium in the Health Professionals Follow-up Study, men in the highest quintile of selenium also had a 65% lower risk relative to those in the lowest quintile. A recent
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