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JNCI Journal of the National Cancer Institute 2000 92(23):1868-1869; doi:10.1093/jnci/92.23.1868
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 23, 1868-1869, December 6, 2000
© 2000 Oxford University Press

EDITORIAL

Preventing Cancer by Disrupting Progression of Precancerous Lesions

William J. Blot

Affiliations of author: International Epidemiology Institute, Ltd., Rockville, MD, and Vanderbilt University Medical Center, Nashville, TN.

Correspondence to: William J. Blot, Ph.D., International Epidemiology Institute, Ltd., 1455 Research Blvd., Suite 550, Rockville, MD 20850.

In this issue of the Journal, Correa et al. (1) provide results from the first reported randomized intervention trial of the effects of anti-Helicobacter pylori treatment and of vitamin supplementation on precancerous lesions of the stomach. The findings are encouraging, with evidence that therapy for H. pylori and supplementation with {beta}-carotene or vitamin C may help limit progression and enhance regression of conditions believed to be in the pathway of gastric cancer.

Randomized clinical trials provide one of the most scientifically rigorous approaches to evaluate potential inhibitors of cancer. Trials directly evaluating cancer as an outcome require large numbers of persons to be followed, often for many years. In some circumstances, an effective alternative is a smaller, shorter . . . [Full Text of this Article]

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