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JNCI Journal of the National Cancer Institute 2000 92(22):1849-1851; doi:10.1093/jnci/92.22.1849
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 22, 1849-1851, November 15, 2000
© 2000 Oxford University Press

BRIEF COMMUNICATION

Infection of Breast Epithelial Cells With Epstein-Barr Virus Via Cell-to-Cell Contact

Peter Speck, Richard Longnecker

Affiliation of authors: Microbiology–Immunology Department, Northwestern University Medical School, Chicago, IL.

Correspondence to: Richard Longnecker, Ph.D., Microbiology–Immunology Department, Northwestern University Medical School, Ward 6-231, 303 East Chicago Ave., Chicago, IL 60611 (e-mail: r-longnecker@nwu.edu).

Epstein-Barr virus (EBV), a human herpesvirus present in more than 90% of adults, is a major viral cofactor in certain tumors of lymphoid and epithelial tissues (1). Persistent infection is associated with malignancies and proliferative syndromes typically of lymphoid and epithelial tissues (1), including Burkitt's lymphoma, Hodgkin's disease, certain adult T-cell lymphomas, and, in epithelium, nasopharyngeal carcinoma and oral hairy leukoplakia. In vitro, EBV efficiently infects, transforms, and immortalizes B cells, yielding lymphoblastoid cell lines (LCLs).

Several studies have associated EBV with breast cancer. Bonnet et al. (2) detected EBV genomes and gene expression in breast cancer lesions by using polymerase chain reaction (PCR) analysis, Southern hybridization, and immunohistochemistry specific for EBV protein EBNA (i.e., EBV nuclear antigen)-1. Labrecque et al. (3) detected EBV in breast cancers by PCR and in situ hybridization. There are descriptions of EBV-associated lymphomas (4,. . . [Full Text of this Article]

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