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JNCI Journal of the National Cancer Institute 2000 92(22):1800-1801; doi:10.1093/jnci/92.22.1800
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 22, 1800-1801, November 15, 2000
© 2000 Oxford University Press

NEWS

Folate Gains Momentum as a Vehicle for Drug Delivery

Brian Vastag

Mothers advising their young ones to take vitamins probably never had this in mind. Folate, one of the B vitamins, is sneaking onto the drug development scene as a possible Trojan horse, able to slip drugs, imaging compounds, or even DNA directly into unsuspecting tumors.

Abundant in leafy green vegetables and nuts, folate is essential for healthy chromosomes and cell division. Most normal cells soak it up via a finicky chemical pathway that rejects all but the purest form of the molecule.

But tumor cells need more and more of the vitamin for accelerated . . . [Full Text of this Article]


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