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JNCI Journal of the National Cancer Institute 2000 92(22):1791-1793; doi:10.1093/jnci/92.22.1791
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 22, 1791-1793, November 15, 2000
© 2000 Oxford University Press

EDITORIAL

Cigarette Smoking and Microsatellite Instability: Causal Pathway or Marker-Defined Subset of Colon Tumors?

Alfred I. Neugut, Mary Beth Terry

Affiliations of authors: A. I. Neugut (Department of Medicine and Division of Epidemiology), M. B. Terry (Division of Epidemiology), Mailman School of Public Health and Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY.

Correspondence to: Alfred I. Neugut, M.D., Ph.D., Division of Oncology, New York Presbyterian Hospital, 630 W. 168th St., PH18–127, New York, NY 10032 (e-mail: ain1@columbia.edu).

When the average person thinks of cigarette smoking and cancer, the cancers that come to mind are those of the lung and upper aerodigestive tract. Cancer researchers have also long recognized the etiologic association of cigarette smoking with a number of other cancers, such as those of the bladder and pancreas. Until quite recently, however, colon cancer, one of the most common cancers in the United States, was not recognized as being associated with cigarette smoking, this despite the fact that numerous studies (1–3) consistently found an association between cigarette smoking and adenomas, the precursor lesions for most cases of colon cancer.

This seeming paradox, that smoking may be related to colorectal adenomas but not to cancer, . . . [Full Text of this Article]

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