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JNCI Journal of the National Cancer Institute 2000 92(22):1787; doi:10.1093/jnci/92.22.1787
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 22, 1787, November 15, 2000
© 2000 Oxford University Press

IN THIS ISSUE

Colon Cancer Risk Factors and Microsatellite Instability

Studies on the association between smoking and colon cancer have not consistently found a link. However, there may be subtypes of colon tumors for which smoking is biologically relevant. Slattery et al. (p. 1831) examined molecular aspects of colon tumors from subjects in a case–control study. They looked particularly at microsatellite instability (MSI), a pathologic feature of some colon tumors in which alterations are found in short nucleotide repeated DNA sequences. They also collected data on lifestyle factors of study subjects using questionnaires. MSI, found in 17% . . . [Full Text of this Article]

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