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JNCI Journal of the National Cancer Institute 2000 92(21):1779-1780; doi:10.1093/jnci/92.21.1779
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 21, 1779-1780, November 1, 2000
© 2000 Oxford University Press

BRIEF COMMUNICATION

Molecular Analysis of Urine Sediment for Follow-up of Urinary Tract Cancers

Pei-Wen Chiang, Anne Schneider, Stéphane Borgnat, Marie-Pierre Gaub, Pierre Oudet, David M. Kurnit, Didier Jacqmin

Affiliations of authors: P.-W. Chiang (Department of Pediatrics), D. M. Kurnit (Departments of Pediatrics and Human Genetics), University of Michigan Medical Center, Ann Arbor; A. Schneider, S. Borgnat, M.-P. Gaub, P. Oudet, D. Jacqmin, Hopitaux Universítaires de Strasbourg Molecular Biology and Urology Departments, Strasbourg, France.

Correspondence to: David M. Kurnit, M.D., Ph.D., University of Michigan Medical School, MSRB I, Rm. 3520, Ann Arbor, MI 48109-0650 (e-mail: sesame@umich.edu).

Aberrations of the ratio between the copy numbers of two alleles of heterozygotes (microsatellite analyses) (1–5) or between the copy numbers of two different genes (quantitative polymerase chain reaction [QPCR]) (6–8) can be used to detect the abnormal genomes of cancer cells.

In this study, we found that these molecular methods were more sensitive than cystoscopy and cytology for monitoring the therapy of bladder tumors. This work was institutionally approved, and all subjects gave written informed consent.

Urine samples were obtained from all subjects, including controls, by spontaneous voiding or through the cystoscope. For cytology, urine samples were passed through Millipore filters (5-µm-pore size; Millipore Corp., Bedford, MA). We performed microsatellite analyses on urine . . . [Full Text of this Article]

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