Skip Navigation

JNCI Journal of the National Cancer Institute 2000 92(20):1628-1629; doi:10.1093/jnci/92.20.1628
© 2000 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Egorin, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Egorin, M. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute, Vol. 92, No. 20, 1628-1629, October 18, 2000
© 2000 Oxford University Press

EDITORIAL

Adenosine Triphosphate-Binding Cassette Proteins and Bioavailability: "We Can Pump You Up (or Out)"

Merrill J. Egorin

Affiliation of author: University of Pittsburgh Cancer Institute, Departments of Medicine and Pharmacology, University of Pittsburgh School of Medicine, PA.

Correspondence to: Merrill J. Egorin, M.D., University of Pittsburgh Cancer Institute, E-1040 Biomedical Sciences Tower, 200 Lothrop St., Pittsburgh, PA 15213 (e-mail: egorinmj@msx.upmc.edu).

The adenosine triphosphate-binding cassette (ABC) superfamily of proteins (1–8) has become a prominent and important area of research in antineoplastic pharmacology and tumor cell biology (9–13). The article by Jonker et al. (14) in this issue of the Journal is an excellent example of the careful types of studies being pursued in this ever-expanding area of research. Consideration of the results of this article and others like it raises fundamental issues and questions in a variety of areas almost as disparate as the various members of the ABC superfamily and the substrates they handle.

The fact that ABC proteins are inherent components of . . . [Full Text of this Article]

REFERENCES


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?