Incipient Angiogenesis

doi:10.1093/jnci/92.2.94

JNCI Journal of the National Cancer Institute 2000 92(2):94-95; doi:10.1093/jnci/92.2.94
© 2000 by Oxford University Press

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Journal of the National Cancer Institute, Vol. 92, No. 2, 94-95, January 19, 2000
© 2000 Oxford University Press

EDITORIALS

Incipient Angiogenesis

Judah Folkman

Correspondence to: Judah Folkman, M.D., Children's Hospital, Hunnewell 103, 300 Longwood Ave., Boston, MA 02115 (e-mail: foss@hub.tch.harvard.edu).

The hypothesis that tumor growth is angiogenesis dependent (1,2)was first proposed in 1971 based on observations that expansionof a tumor mass was limited in the absence of angiogenesis. Sincethen, considerable experimental supporting evidence for this concepthas been assembled from inhibition of angiogenesis by the followingobservations: 1) mechanical separation of tumor cells from theirnearest vascular bed (3), 2) blockade of tumor-derived angiogenicfactors (4), 3) administration of angiogenesis inhibitors (5),4) blockade of endothelial receptors for angiogenic factors(6), 5) endogenous production of angiogenesis . . . [Full Text of this Article]

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