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JNCI Journal of the National Cancer Institute 2000 92(18):1533-1534; doi:10.1093/jnci/92.18.1533
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 18, 1533-1534, September 20, 2000
© 2000 Oxford University Press

CORRESPONDENCE

Re: Biologic Characteristics of Interval and Screen-Detected Breast Cancers

François Eisinger, Claire Juliain-Reynier, Hagay Sobol

Affiliations of authors: F. Eisinger, H. Sobol, Department of Genetic Oncology and Cancer Control/INSERM EPI 9939; C. Julian-Reynier, INSERM U 379, Paoli-Calmettes Institute, Marseille, France.

Correspondence to: Hagay Sobol, M.D., Ph.D., Department of Genetic Oncology and Cancer Control/INSERM EPI 9939, Paoli-Calmettes Institute, 13009 Marseille, France (e-mail: sobol@marseille.inserm.fr).

In their recent work, Gilliland et al. (1) have shown that interval breast cancers, defined as cancers detected within 12 months after a negative mammography, are frequently high-grade, rapidly growing, and aggressive cancers. In particular, tumor proliferation rate and p53 overexpression are independent determinants of interval breast cancers, and these characteristics are seen more often among patients who are younger than 50 years of age. These features are reminiscent of what . . . [Full Text of this Article]

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