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JNCI Journal of the National Cancer Institute 2000 92(18):1466-1469; doi:10.1093/jnci/92.18.1466
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 18, 1466-1469, September 20, 2000
© 2000 Oxford University Press

NEWS

Calories and Cancer: Can We Starve Our Way to Health?

Bob Kuska

In 1935, a nutritionist at Cornell University named Clyde McCay reported that in a series of experiments involving laboratory rats, he found that those eating a low-calorie, high-nutrient diet lived several months longer than their normally fed cage mates, a major improvement in lifespan for these short-lived animals. The implication being: cut calories, live longer.

As the years passed, many molecular biologists have remained skeptical of the finding. Like the line from the movie Jerry Maguire, "Show me the money," molecular biologists have demanded, "Show us the mechanisms." And that is where the conversation came screeching to a halt. With limited data and laboratory tools at their disposal, scientists could not even begin to contemplate how to isolate the cellular mechanisms influenced by caloric restriction.

But that could soon change in the new century. Pointing to the arrival of genomics and higher-powered laboratory technologies, scientists say the field . . . [Full Text of this Article]

Age More Slowly

Show Us the Mechanisms

Big Picture


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