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JNCI Journal of the National Cancer Institute 2000 92(16):1292-1294; doi:10.1093/jnci/92.16.1292
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 16, 1292-1294, August 16, 2000
© 2000 Oxford University Press

NEWS

Lung Project Update Raises Issue Of Overdiagnosing Patients

Laura Newman

Several screening tests are becoming popular based on only short-term survival data and with no evidence that they reduce the rate of late-stage cancers and cancer-specific mortality. An extended follow-up study of the Mayo Lung Project in this issue of the Journal and a recent outcomes analysis of 20 major cancers show no overall mortality reduction despite increases in survival from the date of diagnosis. The authors of both papers say that there is a very real concern about harm that must be addressed, a possibility that often gets short shrift.

The 20-year Mayo Lung Project extended follow-up study (p. 1308) suggests that a phenomenon known as overdiagnosis —finding disease that may be clinically irrelevant—was a major factor in explaining the survival/mortality differential between a group of patients aggressively screened for lung . . . [Full Text of this Article]

Overdiagnosis Bias

Limitations of Survival Analysis

Leveling With Patients


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