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JNCI Journal of the National Cancer Institute 2000 92(16):1282-1283; doi:10.1093/jnci/92.16.1282
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 16, 1282-1283, August 16, 2000
© 2000 Oxford University Press

EDITORIALS

Cyclin D1 and Esophageal Adenocarcinoma Risk: How Good Does a Marker Have to Be?

Joel L. Weissfeld

Correspondence to: Joel L. Weissfeld, M.D., M.P.H., University of Pittsburgh Cancer Institute, Keystone 510, 3520 Fifth Ave., Pittsburgh, PA 15213 (e-mail: jwepid@imap.pitt.edu).

As a result of rapid and dramatic increases in incidence during the past 20–25 years, adenocarcinoma has eclipsed squamous cell carcinoma as the most frequent histopathologic esophageal cancer diagnosis in the United States and in other western countries (1). Adenocarcinoma and squamous cell carcinoma of the esophagus are epidemiologically distinct entities. Any coherent understanding of esophageal adenocarcinoma risk must explain the substantial associations with the male sex and the white race. Although obesity and some aspects of cigarette smoking history may contribute to risk, a growing body of evidence suggests that gastroesophageal reflux leads to a metaplastic change . . . [Full Text of this Article]

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