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JNCI Journal of the National Cancer Institute 2000 92(15):1200-1202; doi:10.1093/jnci/92.15.1200
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 15, 1200-1202, August 2, 2000
© 2000 Oxford University Press

NEWS

Mixed Moniker: ‘Mini’ Marrow Transplants Fuel Excitement, Concern

Brian Vastag

With traditional allogeneic bone marrow and stem cell transplants, toxic pre-transplant treatments wipe out patients’ immune systems and cause severe side effects. Post transplant, the dual threats of unchecked infection and graft-versus-host disease kill as many matched sibling transplant recipients—between 20% and 40%, depending on age and other factors—as the underlying cancer will, according to the International Bone Marrow Transplant Registry.

People who survive the ordeal would cheer the chance to get through it without traveling to the brink and back. They would also meet the suggestion of transplants as an outpatient treatment with scoffs of incredulity.

Yet these are the aspirations of a movement among bone marrow transplant specialists. Across the globe, these researchers are developing what they call low-dose, "mini" transplants, soothing terms that conjure images of a quick trip to the . . . [Full Text of this Article]

A Plethora of Protocols

A Misleading Moniker


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