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JNCI Journal of the National Cancer Institute 2000 92(15):1198-1199; doi:10.1093/jnci/92.15.1198
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 15, 1198-1199, August 2, 2000
© 2000 Oxford University Press

EDITORIALS

Optimizing Dendritic Cell Function by Genetic Modification

H. Kim Lyerly, Tim Clay, Michael A. Morse

Affiliations of authors: H. K. Lyerly (Departments of Surgery, Immunology, and Pathology), T. Clay (Department of Surgery), M. A. Morse (Department of Medicine), Duke University Medical Center, Durham, NC.

Correspondence to: H. Kim Lyerly, M.D., Box 2606, Duke University Medical Center, Durham, NC 27710 (e-mail: k.lyerly@cgct.duke.edu).

The potential for effective immune therapy for cancer has been met with considerable enthusiasm because of a number of fundamental advances in our understanding of the immune responses to cancer. First, previous questions about the existence of tumor antigens have largely been answered, since tumor-associated and tumor-specific antigens clearly exist and, when they are recognized by antigen-specific T cells, can lead to cell lysis. Second, the requirements for initiating T-cell-mediated immune responses have been elucidated and include a first signal (the presentation of antigen within the groove of MHC [i.e., major histocompatibility complex] molecules) and a second signal (the interaction of costimulatory molecules with T cells). The central role of antigen-presenting cells, particularly dendritic cells, in inducing the appropriate immune responses is becoming better understood (1). Since the induction of primary . . . [Full Text of this Article]

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