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JNCI Journal of the National Cancer Institute 2000 92(15):1196-1197; doi:10.1093/jnci/92.15.1196
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 15, 1196-1197, August 2, 2000
© 2000 Oxford University Press

EDITORIALS

Predicting Breast Cancer: the Search for a Model

Mary B. Daly, Eric A. Ross

Affiliation of authors: Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA.

Correspondence to: Mary B. Daly, M.D., Ph.D., Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Ave., Philadelphia, PA 19111 (e-mail: mb_daly@fccc.edu).

The recent success of the National Surgical Adjuvant Breast and Bowel Project (NSABP) tamoxifen chemoprevention trial (1) and the increasing availability of novel agents targeting the early stages of carcinogenesis have resulted in a renewed interest in chemoprevention, in general, and in the need to more accurately assess cancer risk to identify appropriate candidates for participation in cancer prevention trials and to monitor early preclinical events. In the case of breast cancer, the epidemiologic literature is replete with studies describing various demographic, reproductive, and medical factors associated with risk. These risk factors have been quantified in a mathematical model developed by Gail et al. (2), which predicts the risk for breast cancer on the basis of age, race, . . . [Full Text of this Article]

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