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JNCI Journal of the National Cancer Institute 2000 92(14):1121-1123; doi:10.1093/jnci/92.14.1121
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 14, 1121-1123, July 19, 2000
© 2000 Oxford University Press

NEWS

Research Seeks Links Between Cancer, Gene–Environment Interactions

Nancy J. Nelson

Even though cancer can be considered both a genetic and environmental disease, 50 years of epidemiologic research suggests that the vast majority of cancer is caused by environmental and lifestyle exposure to tobacco smoke, alcohol, viruses, drugs, and radiation.

Now, scientists are studying specific gene–environment interactions that contribute to cancer risk. The strategy is to try to find specific gene alterations involved in the well-established pathways linking an exposure to a particular cancer, such as sun and melanoma, hormones and breast/prostate cancers, and tobacco smoke and lung/bladder cancers.

In contrast to alterations found in cancer-prone families, such as BRCA1/2 and APC, mutations in some of the genes now being studied are present in a large proportion of the general population and are thought . . . [Full Text of this Article]

Bladder Cancer and Smoking

Cooked Meat and Breast Cancer

Immigration Patterns

Changing Focus


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