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JNCI Journal of the National Cancer Institute 2000 92(14):1114-1115; doi:10.1093/jnci/92.14.1114
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 14, 1114-1115, July 19, 2000
© 2000 Oxford University Press

EDITORIAL

Familial Aggregation: Sorting Susceptibility From Shared Environment

Gloria M. Petersen

Correspondence to: Gloria M. Petersen, Ph.D., Mayo Clinic, 200 First St., S.W., Rochester, MN 55905 (e-mail: peterg@mayo.edu).

The contribution of family-based studies to elucidating the etiology of cancer has not been as widely appreciated as deserved. During the past decade, headlines have repeatedly trumpeted the discoveries of many cancer genes. In a number of cases, the discoveries have been translated to the clinic to improve cancer risk assessment and more precisely to devise potential interventions (1–5). In the laboratory, moreover, new avenues have been opened to characterizing the functional role of these genes (6). However, none of this would have been possible without the painstaking research over many years by hundreds of epidemiologists, clinicians, and genetic epidemiologists. They have labored to piece together the . . . [Full Text of this Article]

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