© 2000 by Oxford University Press
Journal of the National Cancer Institute, Vol. 92, No. 14, 1111,
July 19, 2000
© 2000 Oxford University Press
IN THIS ISSUE |
Epidemiologic and laboratory studies have indicated that nonsteroidal anti-inflammatory drugs (NSAIDs) may help prevent colon cancer. Previous work had examined NSAID-induced apoptotic cell death in relation to the well-known inhibition of cyclooxygenase enzymes in colorectal cancer cells. Because NSAID-induced apoptosis can proceed independently of cyclooxygenase inhibition, however, Shureiqi et al. (p. 1136) investigated in two colorectal cancer cell lines another enzyme affected by NSAIDs, the lipoxygenase 15-LOX-1. They found that NSAIDs induced the expression and activity of 15-LOX-1, which were accompanied by apoptosis and inhibition of cell growth. Apoptosis
Risk of Leukemia Following Testicular Cancer
Hepatocellular Carcinoma and Familial Risk
Breast-Conserving Therapy and Mastectomy
Multiple Births and Ovarian Cancer
Population Stratification and Quantification of Bias