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JNCI Journal of the National Cancer Institute 2000 92(14):1111; doi:10.1093/jnci/92.14.1111
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 14, 1111, July 19, 2000
© 2000 Oxford University Press


IN THIS ISSUE

Apoptosis in Colon Cancer Cells

Epidemiologic and laboratory studies have indicated that nonsteroidal anti-inflammatory drugs (NSAIDs) may help prevent colon cancer. Previous work had examined NSAID-induced apoptotic cell death in relation to the well-known inhibition of cyclooxygenase enzymes in colorectal cancer cells. Because NSAID-induced apoptosis can proceed independently of cyclooxygenase inhibition, however, Shureiqi et al. (p. 1136) investigated in two colorectal cancer cell lines another enzyme affected by NSAIDs, the lipoxygenase 15-LOX-1. They found that NSAIDs induced the expression and activity of 15-LOX-1, which were accompanied by apoptosis and inhibition of cell growth. Apoptosis . . . [Full Text of this Article]

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Breast-Conserving Therapy and Mastectomy

Multiple Births and Ovarian Cancer

Population Stratification and Quantification of Bias


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