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JNCI Journal of the National Cancer Institute 2000 92(13):1028-1029; doi:10.1093/jnci/92.13.1028
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 13, 1028-1029, July 5, 2000
© 2000 Oxford University Press

EDITORIALS

Estrogen Deficiency: In Search of Symptom Control and Sexuality

Charles L. Loprinzi, Debra Barton

Affiliation of authors: Division of Medical Oncology, Mayo Clinic, Rochester, MN.

Correspondence to: Charles L. Loprinzi, M.D., Division of Medical Oncology, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905 (e-mail: cloprinzi@mayo.edu).

Menopausal symptoms can be very prominent problems in women as they approach the age of 50 years and beyond. For at least three reasons, such problems are exacerbated in patients who have had breast cancer. First, cytotoxic chemotherapy in premenopausal women can cause an abrupt menopause, with marked symptoms. Second, the most commonly used antineoplastic drug in the world, tamoxifen, causes, as its most prominent toxic effect, hot flashes. Third, estrogen therapy, the most widely used treatment of women with menopausal symptoms, is often not used in patients with a history of breast cancer because of concerns about what estrogen might do regarding breast cancer.

The article by Ganz et al. (1) in this issue of the Journal describes a group of breast cancer survivors with marked menopausal-associated symptoms. This study incorporated a number of design strengths. The authors used a randomized study method with a control group. . . . [Full Text of this Article]

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