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JNCI Journal of the National Cancer Institute 2000 92(12):959-960; doi:10.1093/jnci/92.12.959
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 12, 959-960, June 21, 2000
© 2000 Oxford University Press

EDITORIALS

Chemoprevention of Lung Cancer Is Proving Difficult and Frustrating, Requiring New Approaches

Gilbert S. Omenn

Correspondence to: Gilbert S. Omenn, M.D., Ph.D., The University of Michigan, M7324 Medical Science Bldg., Ann Arbor, MI 48109-0626 (e-mail: gomenn@umich.edu).

The long-awaited results from EUROSCAN (i.e., the European Study on Chemoprevention With Vitamin A and N-Acetylcysteine), the randomized two-by-two factorial trial of vitamin A (retinyl palmitate) and N-acetylcysteine in patients with treated cancers of the lung or head and neck, show no benefit from either agent alone or from the combination. Among 2592 participants who received maximal tolerable doses for 2 years with a mean follow-up of 49 months, 916 experienced recurrence, second primary tumor, or death. The findings were analyzed exhaustively (1).

Hypothesis-driven chemoprevention of lung cancers, when put to the test of randomized large-scale clinical trials, so far has been disappointing, unlike important successes with selective estrogen . . . [Full Text of this Article]

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