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JNCI Journal of the National Cancer Institute 2000 92(11):866-868; doi:10.1093/jnci/92.11.866
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 11, 866-868, June 7, 2000
© 2000 Oxford University Press

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Plasminogen Activator Proteins Tested as Prognostic Markers

Nancy J. Nelson

A controversial area in breast cancer treatment is the management of node-negative patients. It is known that 10 years after surgery and radiation about 30% of node-negative patients will relapse and 70% remain disease-free. The question is how to distinguish between these two groups so that chemotherapy can be given to those likely to relapse.

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A team of German investigators reporting at the annual meeting of the American Association for Cancer Research in San Francisco claims to have an answer. They believe that they can identify patients whose chance of recurrence is so small that they could forego chemotherapy. The molecules that allow them to do this are two prognostic/predictive markers, uPA, (urokinase-type plasminogen activator), and PAI-1 (plasminogen activator inhibitor-1).

In earlier work published in the British Journal of Cancer in 1999, the researchers, including Nadia Harbeck, M.D., and Manfred Schmitt, . . . [Full Text of this Article]

Measuring Protein Levels

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