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JNCI Journal of the National Cancer Institute 2000 92(10):773; doi:10.1093/jnci/92.10.773
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 10, 773, May 17, 2000
© 2000 Oxford University Press

IN THIS ISSUE

Cancer Risk and the ATM Gene

Ataxia-telangiectasia (A-T) is an autosomal recessive disorder caused by mutation of the ATM (A-T-mutated) gene. Individuals with one mutated ATM gene, called A-T carriers, have an increased risk of breast cancer. The ATM protein is activated in response to double-stranded breaks caused by ionizing radiation, and the activated protein is involved in the regulation of various cell cycle checkpoints. In this issue, Khanna (p. 795) reviews the molecular structures of the ATM gene and ATM protein. She describes how the activated ATM protein signals the presence of DNA damage . . . [Full Text of this Article]

Gene Methylation and Breast Cancer

p53 Mutational Hotspots and Smoke Components

Patterns of Melanoma Mortality Among Whites

Cervical Cancer Screening in Low-Resource Settings

Dietary Fat and Breast Cancer


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