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JNCI Journal of the National Cancer Institute 2000 92(1):74-75; doi:10.1093/jnci/92.1.74
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 1, 74-75, January 5, 2000
© 2000 Oxford University Press

BOOK REVIEW

Inherited Susceptibility to Cancer: Clinical, Predictive and Ethical Perspectives

William D. Foulkes, Shirley V. Hodgson, eds. Cambridge (U.K.): Cambridge University Press, 1998. 456 pp., illus. $95.00. ISBN 0-521-56340-2

Randall Burt

Correspondence to: Randall Burt, M.D., University of Utah School of Medicine, GI Division, 50 N. Medical Dr., Salt Lake City, UT 84132.

Cancer has historically been considered a disease of environmental exposure with the exception of a few well-described, but rare, inherited syndromes. In the past 2 decades, it has become increasingly apparent that inherited susceptibility plays a much larger role in human cancer. Numerous cancer susceptibility genes have been identified, some of which relate to the known inherited syndromes and some of which do not. Genes that confer susceptibility to colon, breast, uterine, renal, and other malignancies are now known. Somatic inactivation of the genes related to inherited cancer syndromes has been found in many cases to be important to . . . [Full Text of this Article]


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