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JNCI Journal of the National Cancer Institute 2000 92(1):1; doi:10.1093/jnci/92.1.1
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 1, 1, January 5, 2000
© 2000 Oxford University Press

IN THIS ISSUE

Cell Environment and Etoposide Resistance

Molecular signals in a cancer cell's microenvironment may trigger survival-promoting mechanisms, thereby leading to resistance to chemotherapy. Taylor et al. (p. 18) examined three survival-promoting pathways, individually or in combination, to test their ability to prevent cell death in human B lymphoma cells treated with the drug etoposide. The authors found that the combination of all three survival signals reduced etoposide-induced apoptotic cell death by approximately fourfold, a difference that was statistically significant. Additional experiments by the researchers shed light on the molecular mechanism of the . . . [Full Text of this Article]

Smoking and Sex-Specific Gene Expression

Alternative Therapy and Breast Cancer

Modeling Tamoxifen's Efficacy

Treating Advanced Prostate Cancer

Germ Cell Tumors and Hematologic Neoplasia


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