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JNCI Journal of the National Cancer Institute 1999 91(9):747-749; doi:10.1093/jnci/91.9.747
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 9, 747-749, May 5, 1999
© 1999 Oxford University Press

EDITORIALS

The Rising Incidence of Gastric Cardia Cancer

Susan S. Devesa, Joseph F. Fraumeni, Jr.

Affiliation of authors: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

Correspondence to: Susan S. Devesa, Ph.D., National Institutes of Health, Executive Plaza South, Rm. 8048, Bethesda, MD 20892.

Recent estimates of global cancer statistics have ranked stomach cancer behind only lung cancer in the number of new cases and deaths worldwide (1). Incidence and mortality rates for stomach cancer in the United States and developed countries of Europe have decreased steadily for many years, while the rates still remain considerably higher in many developing countries (2-5). In the face of the overall decline in stomach cancer, a number of investigators around the world have reported rising incidence rates for gastric cardia adenocarcinoma, almost always in conjunction with increases in esophageal adenocarcinoma (6-15). In the United States, based on data from the Surveillance, Epidemiology, and End Results (SEER)1 program, incidence rates for both gastric cardia and esophageal adenocarcinomas have increased 4%-10% per year among men since 1976, more rapidly than for any other type of cancer (6. . . [Full Text of this Article]

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