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JNCI Journal of the National Cancer Institute 1999 91(8):718-721; doi:10.1093/jnci/91.8.718
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 8, 718-721, April 21, 1999
© 1999 Oxford University Press

BRIEF COMMUNICATIONS

Alterations in NF{kappa}B Activation in T Lymphocytes of Patients With Renal Cell Carcinoma

Robert G. Uzzo, Peter E. Clark, Patricia Rayman, Tracy Bloom, Lisa Rybicki, Andrew C. Novick, Ronald M. Bukowski, James H. Finke

Affiliations of authors: R. G. Uzzo, P. E. Clark (Departments of Immunology, Lerner Research Institute, and Urology), P. Rayman, T. Bloom (Department of Immunology, Lerner Research Institute), L. Rybicki (Department of Biostastics), A. C. Novick (Department of Urology), R. M. Bukowski (Departments of Immunology, Lerner Research Institute, and Urology, and Experimental Therapeutics Program), J. H. Finke (Departments of Immunology, Lerner Research Institute, and Urology, and Experimental Therapeutics Program), The Cleveland Clinic Foundation, OH.

Correspondence to: Robert G. Uzzo, M.D., Department of Immunology, NB3-29, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195.

T cells represent an important component in the development of an effective antitumor immune response. Although most solid tumors are infiltrated with T lymphocytes, including some clones capable of preferentially recognizing malignant cells, T-cell immunity fails to develop adequately in patients with tumors (1-4). Defects in proliferation and effector functions have been noted in peripheral blood T cells, while more pronounced alterations have been reported for T cells infiltrating the tumor (5,6). Moreover, cytokine gene expression normally associated with the development of an effective antitumor immune response is absent in the tumor (7).

Alterations in expression and activity of intracellular signaling elements have been reported in T cells from patients with tumors (8). These include defective activation of the transcription factor NF{kappa}B in both tumor-bearing mice and patients with renal cell carcinoma (RCC) (9,10. . . [Full Text of this Article]

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