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JNCI Journal of the National Cancer Institute 1999 91(8):664-666; doi:10.1093/jnci/91.8.664
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 8, 664-666, April 21, 1999
© 1999 Oxford University Press

NEWS

Cell Death Genes May Hold Clues to Preserving Fertility After Chemotherapy

Tom Reynolds

In hope of finding treatments to preserve fertility and fend off premature menopause, scientists are dissecting the genetic pathway driving cell death in the oocytes of women undergoing cancer therapy.

Other researchers, meanwhile, are working toward the same goal by refining ovary cryopreservation, a technique that involves removing and freezing portions of the ovary and reimplanting them later.

And combining the two approaches might further improve the chances of success, according to leading investigators in the field.

Oocytes are among the cells most sensitive to collateral damage from both chemotherapy and radiotherapy, raising concerns and potential health risks for women surviving diseases such as breast cancer, Hodgkin's disease, and leukemia. Women relatively close to menopausal age are most vulnerable: One study of chemotherapy-treated breast cancer patients found that 92% of women over 40 had irreversible amenorrhea, compared with 31% of those under 40. The recent . . . [Full Text of this Article]

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