© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 7, 579-581,
April 7, 1999
© 1999 Oxford University Press
EDITORIALS |
Insulin-Like Growth Factor-I: a Key Regulator of Human Cancer Risk?
Affiliations of authors: K. D. Burroughs, S. E. Dunn, J. C. Barrett (Laboratory of Molecular Carcinogenesis), J. A. Taylor (Laboratory of Molecular Carcinogenesis, Epidemiology Branch), National Institute of Environmental Health Sciences, Research Triangle Park, NC.
Correspondence to: Jack A. Taylor, M.D., Ph.D., National Institute of Environmental Health Sciences, P.O. box 12233, Mail Drop A3-05, Research Triangle Park, NC, 27709 (e-mail: taylor@niehs.nih.gov).
In this issue of the Journal, Ma et al. (1) report the
results of a nested case-control study that show an association
between colorectal cancer risk in men and elevated plasma levels of
insulin-like growth factor-I (IGF-I) and decreased plasma levels of
IGF-binding protein-3 (IGFBP-3). Importantly, this study demonstrates
these effects by using plasma samples drawn years before the clinical
appearance of the tumor, thus minimizing the chance that plasma levels
are influenced by the disease process. This study follows reports
demonstrating associations between levels of IGF-I and/or IGFBP-3 and
the risk for cancers of the breast, prostate, and lung, suggesting that
IGF-I is an important indicator of risk for the most prevalent forms of cancer
in Western society (2-5). In fact, IGF-I levels appear to have a
stronger association than most other risk factors for
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