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JNCI Journal of the National Cancer Institute 1999 91(7):575; doi:10.1093/jnci/91.7.575
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 7, 575, April 7, 1999
© 1999 Oxford University Press

IN THIS ISSUE

Occult Primary Tumor Sites

Head and neck squamous cell carcinoma (HNSCC) with an unknown primary tumor site presents as a cervical lymph node metastasis without an obvious mucosal lesion. Califano et al. (p. 599) have investigated whether localization of the primary tumor site can be achieved by detecting, in histologically benign mucosa, genetic alterations identical to those found in the metastatic lesion. Microsatellite analysis was performed on metastatic tumors and histologically benign surveillance biopsy specimens from 18 patients. In 10 patients, at least one surveillance biopsy specimen exhibited genetic alterations identical to those in the metastatic lesion, and three of . . . [Full Text of this Article]

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