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JNCI Journal of the National Cancer Institute 1999 91(6):487; doi:10.1093/jnci/91.6.487
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 6, 487, March 17, 1999
© 1999 Oxford University Press

IN THIS ISSUE

Measuring Response in Solid Tumors

Tumor shrinkage is a common end point used in screening new cytotoxic agents. The standard criterion for partial response is a decrease of 50% or more in the sum of individual products of two tumor measurements: the maximum diameter of a lesion and the largest diameter perpendicular to it. Theoretically, the simple sum of the maximum diameters of individual tumors is more linearly related to cell kill than is the sum of the bidimensional products. James et al. (p. 523) hypothesized that a 30% decrease in the sum of the maximum diameters of . . . [Full Text of this Article]

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