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JNCI Journal of the National Cancer Institute 1999 91(4):304-305; doi:10.1093/jnci/91.4.304
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 4, 304-305, February 17, 1999
© 1999 Oxford University Press

EDITORIALS

Skewed X-Chromosome Inactivation: Cause or Consequence?

Carolyn J. Brown

Affiliation of author: Department of Medical Genetics,University of British Columbia, Vancouver.

Correspondence to: Carolyn J. Brown, Ph.D., Department of Medical Genetics, University of British Columbia, 6174 University Blvd., Vancouver, British Columbia, Canada V6T 1Z3 (e-mail: cbrown@unixg.ubc.ca).

X-chromosome inactivation occurs early during female mammalian development to transcriptionally silence one of the two X chromosomes, thereby achieving dosage compensation with males who have only a single X chromosome and the sex-determining Y chromosome (1). The choice of which X chromosome to inactivate is generally random in somatic tissue; however, once chosen, the inactivation is stably maintained, and the same chromosome is inactivated in all progeny cells. Therefore, females are mosaics of two populations of cells that differ in the X chromosome that is active. For more than three decades, researchers have used this mosaicism as a tool to examine the potential clonal origin of neoplasias in females (2), since, if the tumor(s) arose from a single cell after the time of X-chromosome inactivation, . . . [Full Text of this Article]

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