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JNCI Journal of the National Cancer Institute 1999 91(4):302-303; doi:10.1093/jnci/91.4.302
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 4, 302-303, February 17, 1999
© 1999 Oxford University Press

EDITORIALS

Current Status of Sentinel Lymph Node Surgery for Breast Cancer

David Krag

Correspondence to: David Krag, M.D., Department of Surgery, University of Vermont, E309 Given Bldg., Burlington, VT 05405.

In 1997, Veronesi et al. (1) reported in the Lancet on their sentinel lymph node experience in a series of 163 patients with breast cancer. The day before surgery, a small volume of colloidal human albumin labeled with technetium 99m was injected subdermally over the tumor in these patients. Gamma camera imaging was performed, and a hand-held gamma probe was used to guide the surgical resection of the sentinel nodes (SNs). The use of blue dye was not reported. In 98% of the cases, at least one SN could be identified surgically. The false-negative rate (i.e., number of cases with negative SNs but positive non-SNs x 100/total number of cases with positive nodes) was 5%. The overall accuracy was 98%. Frozen section analysis had a higher false-negative rate of 36%.

Now, this group from Milan reports in this issue of the Journal on 376 cases (i.e., the 163 . . . [Full Text of this Article]

COMPREHENSIVE DETECTION OF SNS

COMPLETE STAGING OF LYMPH NODES

REGIONAL CONTROL AND SURVIVAL

INTRAOPERATIVE PATHOLOGY

PREVIOUS EXCISIONAL BIOPSY

METHOD OF TRACER INJECTION

GAMMA CAMERA IMAGING

RADIATION EXPOSURE

NOTES

REFERENCES


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