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JNCI Journal of the National Cancer Institute 1999 91(3):279-282; doi:10.1093/jnci/91.3.279
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 3, 279-282, February 3, 1999
© 1999 Oxford University Press

BRIEF COMMUNICATION

Genetic Mapping of the Thymoma Susceptible Locus, Tsr1, in BUF/Mna Rats

Atsushi Oyabu, Kyoko Higo, Chunlin Ye, Hiroyuki Amo, Mitsuhiro Saito, Shigeru Yagyu, Hiroyuki Morita, Kenji Maeda, Tadao Serikawa, Masahide Takahashi, Mutsushi Matsuyama

Affiliations of authors: A. Oyabu, H. Morita, K. Maeda (Department of Internal Medicine, Daiko Medical Center), M. Saito, M. Takahashi (Department of Pathology), Nagoya University School of Medicine, Japan; K. Higo, C. Ye, M. Matsuyama (Department of Pathology), S. Yagyu (Institute for Comprehensive Medical Sciences), Fujita Health University School of Medicine, Toyoake, Japan; H. Amo, Aichi Women's College, Aichi-ken, Japan; T. Serikawa, Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Japan.

Correspondence to: Mutsushi Matsuyama, M.D., Department of Pathology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi-ken 470-1192, Japan (e-mail: mmatsuya@fujita-hu.ac.jp).

BUF/Mna (BUF) rats have been reported to develop spontaneous thymomas in virtually 100% of animals (1-4). The thymomas in BUF rats have been defined as epithelial cell tumors, having varying proportions of lymphocytic components that are non-neoplastic in nature (5,6). These thymomas start to develop in rats at the age of 9 months and they reach their maximum growth by the time the animals are 18 months of age (7). It was found that thymoma development in this strain was regulated by an autosomal dominant gene, Tsr1 (8). However, the chromosomal location of the gene is not yet determined. The aim of this study is to determine the location of Tsr1, using microsatellite markers and backcross of rats between the thymoma-susceptible BUF strain and thymoma nonsusceptible ACI/NMs (ACI) strain.

A highly . . . [Full Text of this Article]

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